DESCRIPTION. Clear, colourless to viscous solution, with pH between 2.9 and 3.7, and osmolality between 230 and 290 mOsm/kg. Midazolam 2 mg/ml should be used if higher doses are required. When Midazolam is used to maintain anaesthesia, it is recommended that equipment such as syringe pumps or volumetric infusion pumps should always be used to control infusion rates. This is due to an increase of approximately 50% in the volume of distribution corrected for total body weight. 5 to 25°C. ARTG Start Date. When midazolam is injected i.v., the plasma concentration-time curve shows one or two distinct phases of distribution. Giving midazolam by injection into a vein can sometimes cause severe breathing problems which could rarely lead to brain damage or be fatal. To view the changes to a medicine you must sign up and log in. Midazolam, Versed®, is used for pets like dogs and cats, as a sedative. Benzodiazepine respiratory depressant effects are more serious in patients with respiratory disease. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION. Storage Temp. Each 50 ml vial contains 50 mg midazolam. midazolam. Initially 50–200 micrograms/kg, to be administered over at least 3 minutes, followed by (by continuous intravenous infusion) 30–120 micrograms/kg/hour, adjusted according to response, initial dose may not be required and lower maintenance doses needed if opioid analgesics also used; reduce dose (or reduce or omit initial dose) … Midazolam is almost entirely eliminated by biotransformation. midazolam, in particular since CYP3A4 also exists in the upper gastro-intestinal tract. Exactly how midazolam works is uncertain but it is thought to reduce serotonin levels and reduce acetylcholine levels. Solution for injection / infusion (50 mg / 50 ml) . Midazolam Sandoz 5 mg/ml contains as active substance 5 mg/ml of midazolam as midazolam hydrochloride, and is a clear, slightly yellow solution with pH 2.9 – 3.7 and osmolality of 280 – 330 mOsmol/kg. Each ml contains 3.15 mg (0.14 mmol) of sodium. When midazolam is given with potent analgesics, the latter should be administered first so that the sedative effects of midazolam can be safely titrated on top of any sedation caused by the analgesic. When administered by continuous infusion, a 1-mg/mL midazolam solution can be prepared by mixing the contents of 5-mL vials or by diluting a 50 mg/10 mL commercial midazolam solution with 0.9% sodium chloride injection in 50-mL polypropylene (PP) syringes. - Rifampicin decreased the plasma concentrations of intravenous midazolam by about 60% after 7 days of rifampicin 600 mg o.d. The concomitant use of midazolam with alcohol or/and CNS depressants should be avoided. The major fraction of plasma protein binding is due to albumin. For a full list of excipients, see section 6.1. The solution for injection or infusion is packed in colourless glass type I ampoules. It is therefore recommended to carefully monitor the clinical effects and vital signs during the use of midazolam, taking into account that they may be stronger and last longer after co-administration of a CYP3A4 inhibitor, be it given only once. - Ketoconazole increased the plasma concentrations of intravenous midazolam by 5-fold while the terminal half-life increased by about 3-fold. Postal Address. 60 children aged 2–6 years were enrolled in the study. Dosage form . It is expected that these interactions will be less pronounced for the rectal than for the oral route because the gastro-intestinal tract is by-passed whereas after i.m. - Efavirenz: The 5-fold increase in the ratio of the CYP3A4 generated metabolite α-hydroxymidazolam to midazolam confirms its CYP3A4-inducing effect. The fraction of the dose extracted by the liver has been estimated to be 30 - 60%. The solution should be examined visually before administration. midazolam with a subsequent increase in terminal half-life. In hypovolaemic, vasoconstricted or hypothermic patients the loading dose should be reduced or omitted. One pre-filled syringe must be used for one patient only. Pharmacokinetic interactions with CYP3A4 inhibitors or inducers are more pronounced for oral as compared to i.v. If parenteral midazolam is coadministered with HIV protease inhibitors, treatment setting should follow the description in the above section for azole antifungals, ketoconazole. It should be kept in mind that if midazolam is given orally, its exposure will drastically be higher than the above-mentioned ones, notably with ketoconazole, itraconazole, voriconazole. Start typing to retrieve search suggestions. Midazolam as other benzodiazepines should be avoided in patients with a medical history of alcohol or drug abuse. Overdose of midazolam is seldom life-threatening if the medicinal product is taken alone, but may lead to areflexia, apnoea, hypotension, cardiorespiratory depression and in rare cases to coma. Each pre-filled syringe of 50 ml contains 50 mg midazolam. Midazolam should be used only in a hospital, dentist office, or other clinic setting where any serious side effects can be quickly … Midazolam can be given by mouth, intravenously, or injection … Excipient with known effect: A 50 ml pre-filled syringe contains 157.36 mg (6.84 mmol) of sodium. Australia. During the holidays we are there for you at our different locations as follows: hameln pharma gmbh, Hameln, Germany: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products. Midazolam injection is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine). During prolonged treatment with midazolam in ICU, physical dependence may develop. Midazolam 1mg/ml, solution for injection. Objectives. I.V. The highest incidence to such reactions has been reported the elderly. Nursing mothers should be advised to discontinue breast-feeding for 24 hours following administration of midazolam. It is recommended that the patient is accompanied when returning home after discharge. Each ml of the solution for injection/infusion contains 1 mg midazolam. The elimination half-life in patients with chronic renal failure is similar to that in healthy volunteers. Bella Vista NSW 2153 . The risk for neonates should be taken into account in case of administration of midazolam for any surgery near the term. Such life-threatening incidents are more likely to occur when the injection is given too rapidly or when a high dose is administered (see section 4.8). Standard doses are provided in the table below. Loading... View more photos. - patients with chronic respiratory insufficiency. ... 50 mg /10 mL. MIDAZOLAM INJECTION USP 1 mg/mL and 5 mg/mL midazolam Sterile Solution Preservative-Free THERAPEUTIC CLASSIFICATION Benzodiazepine Premedicant-Sedative-Anesthetic Agent Pfizer Canada Inc. 17300 Trans-Canada Highway Kirkland, Québec H9J 2M5 Date of Revision: October 25, 2017 … Container: Conventional IV bag. Consequently, midazolam should not be used during pregnancy unless clearly necessary and it is preferable to avoid using it for caesarean section. tricyclic antidepressants). When suggestions are available use up and down arrows to review and ENTER to select. In humans, midazolam has been shown to cross the placenta slowly and to enter foetal circulation. Only solutions without visible particles should be used. In patients with renal failure (creatinine clearance < 10 ml/min) the pharmacokinetics of unbound midazolam following a single i.v. Dependence: Use of midazolam - even in therapeutic doses - may lead to the development of physical dependence. 96 - 98% of midazolam is bound to plasma proteins. The following symptoms may occur: headaches, muscle pain, anxiety, tension, restlessness, confusion, irritability, rebound insomnia, mood changes, hallucinations and convulsions. - Posaconazole increased the plasma concentrations of intravenous midazolam by about 2-fold. Each mL contains midazolam hydrochloride equivalent to 5 mg midazolam compounded with 0.8% sodium chloride and 0.01% edetate disodium, with 1% … Alcohol intake should be strongly avoided in case of midazolam administration (see section 4.4). Midazolam is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. 2 mg per 2 mL NDC 70860-600-02 Midazolam Injection, USP 50 mg per 10 mL 70860-601-10 Glass Vial 5 mg per mL 20 mm 10 vials Yes Room Temp. Insufficient data are available on midazolam to assess its safety during pregnancy. With long-term sedation, tolerance may develop and the dose may have to be increased. Midazolam Injection C-IV, 50mg/10mL (5mg/mL) Tell a Friend Print Home » Midazolam Injection C-IV, 50mg/10mL (5mg/mL) Submitted by suncms on Mon, 2013-08-05 13:30. Midazolam is a derivative of the imidazobenzodiazepine group. Flumazenil is to be used with extreme caution in the presence of drugs that reduce seizure threshold (e.g. The desired level of sedation is reached by stepwise titration of midazolam followed by continuous infusion, according to the clinical need, physical status, age and concomitant medication (see section 4.5). Level 5, 7-9 Irvine Place . 2. - Fluconazole and itraconazole both increased the plasma concentrations of intravenous midazolam by 2 – 3-fold associated with an increase in terminal half-life by 2.4-fold for itraconazole and 1.5-fold for fluconazole, respectively. or i.v. Frequency groupings are defined according to the following convention: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000), Not known (cannot be estimated from the available data). Product Category. - Verapamil / diltiazem increased the plasma concentrations of oral midazolam by 3- and 4-fold, respectively. This information is intended for use by health professionals, Midazolam 1 mg/ml solution for injection/infusion in pre-filled syringe. … infusion, its elimination kinetics do not differ from those following bolus injection. Order and delivery times for the turn of the year (deliveries within Germany): hameln pharma ltd, Gloucester, United Kingdom: In hypovolaemic, vasoconstricted or hypothermic patients the maintenance dose should be reduced. For pre-Christmas deliveries, please place your orders before noon on Monday, 21st December 2020. Our offices will remain closed from 24th December 2020 until 03rd January 2021. Moreover, infants born from mothers who received benzodiazepines chronically during the latter stage of pregnancy may have developed physical dependence and may be at some risk of developing withdrawal symptoms in the postnatal period. Animal studies do not indicate a teratogenic effect, but foetotoxicity was observed as with other benzodiazepines. Load: 10-50 mcg/kg (dose range 0.5-4 mg) slow IV injection or infusion over several minutes; repeat q5-15min PRN . Further doses of 1 mg may be given as necessary. The 1 mg/ml product is - Nefazodone increased the plasma concentrations of oral midazolam by 4.6-fold with an increase of its terminal half-life by 1.6-fold. The clearance is not significantly different in obese and non-obese patients. INTAS MIDAZOLAM Midazolam (as hydrochloride) 50 mg/10 mL solution for injection syringe. Tel: +49 (0) 5151 / 80 50 0 When midazolam is used in long-term sedation in ICU, it should be borne in mind that physical dependence on midazolam may develop. Pharmacotherapeutic group: Psycholeptics; hypnotics and sedatives; benzodiazepine derivatives. Midazolam is a short-acting sleep-inducing active substance that is indicated in adults for sedation in intensive care units. The terminal half-life decreased by about 50-60%. 2 mg 5 0 mg To order, call 1-855-273-0154 or visit … Each increment of 1 to 2.5 mg should be injected over 20 to 30 seconds allowing 2 minutes between successive increments. per dose 5 mg), dose to be given at intervals of 2 minutes, maximum total dose 600 micrograms/kg. It also exerts an anxiolytic, an anticonvulsant and a muscle-relaxant effect. The volume of distribution at steady state is 0.7 - 1.2 l/kg. Midazolam is usually given as a single dose just before your surgery or procedure. B. BRAUN MIDAZOLAM 50 mg/50 mL Injection, Intravenous Infusion bottle (AUST R 225697) B. BRAUN MIDAZOLAM 100 mg/100 mL Injection, Intravenous Infusion bottle (AUST R 225696) Who distributes B. BRAUN MIDAZOLAM . B. Braun Australia Pty Ltd . Staggered dosing and dose adjustment should be considered, especially if more than a single i.v. administration, discontinuation, especially abrupt discontinuation of the product, may be accompanied by withdrawal symptoms including withdrawal convulsions (see section 4.4). Each pre-filled syringe of 50 ml contains 50 mg midazolam. Physician Prescribing Information; MIDAZOLAM, Via N+ 10 mg/10 mL, 25 mg/5 mL, 50 mg/10 mL U.S. hameln pharma gmbh ARTG entry for. Please check with your pharmacist for the latest Consumer Medicine Information. Based on data for other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally. Shape . MIDAZOLAM INJECTION (Midazolam Injection, Pfizer standard) 5 mg/1 mL Steriluer Plastic Ampoule. Our offices will remain closed from 24th December 2020 until 03rd January 2021. It allows continued monitoring of the benefit/risk balance of the medicinal product. Midazolam is excreted mainly by renal route (60 - 80% of the injected dose) and recovered as glucuroconjugated alpha-hydroxymidazolam. Midazolam elimination may also be delayed in patients with liver dysfunction or low cardiac output (see section 5.2). Concomitant use of alcohol/CNS depressants. Coma, if it occurs, usually lasts a few hours but it may be more protracted and cyclical, particularly in elderly patients. Adverse reactions listed below are classified according to frequency and System Organ Class (SOC). maintenance dose: doses can range from 0.03 to 0.2 mg/kg/h. The same recommendation may apply also for other azole antifungals (see further), since increased sedative effects of i.v. In healthy volunteers, the elimination half-life of midazolam is between 1.5 - 2.5 hours. Medicine Registered . Midazolam Injection IV Bottle, USP 50 mg/50 mL (1 mg/mL) - Preservative Free This item is packaged with 30 pre-filled 50mL plastic IV bottles per case. Status. Reporting suspected adverse reactions after authorisation of the medicinal product is important. administration anterograde amnesia of short duration occurs (the patient does not remember events that occurred during the maximal activity of the compound). A 50 ml pre-filled syringe contains 157.36 mg (6.84 mmol) of sodium. Users must be familiar with the infusion pump users' manual and with the correct use of the syringe identification system. Other: 50 mg/10 mL (5 mg/mL) Multiple Dose Glass Fliptop Vial (NDC 00409-2596-05) Limited Supply Available. Solution. Additional details are provided in the text following the table. for Health Care Professionals: MIDAZOLAM, Vial 10 mg/10 mL, 25 mg/5 mL, 50 mg/10 mLU.S. Paradoxical reactions such as agitation, involuntary movements (including tonic/clonic convulsions and muscle tremor), hyperactivity, hostility, rage reaction, aggressiveness, paroxysmal excitement and assault, have been reported to occur with midazolam. The elimination half-life of midazolam is prolonged up to six times in the critically ill. The risk of falls and fractures is increased in those taking concomitant sedatives (including alcoholic beverages) and in the elderly. Inhibitors and inducers of CYP3A have the potential to respectively increase and decrease the plasma concentrations and, subsequently, the effects of midazolam thus requiring dose adjustments accordingly. 1 mg/30 seconds. For urgent requirements an emergency staff will be available during the festive period, too. administration the effects of CYP3A4 modulation should not substantially differ from those seen with i.v. Not applicable. It works by inducing sleepiness, decreasing anxiety, and causing a loss of ability to create new memories. The level of sedation should be assessed regularly. After prolonged i.v. Midazolam hydrochloride is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. However, after prolonged infusion in intensive care unit (ICU) patients, the mean duration of the sedative effect in the renal failure population was considerably increased most likely due to accumulation of α-hydroxymidazolam glucuronide. - Aprepitant dose dependently increased the plasma concentrations of oral midazolam by 3.3-fold after 80 mg/day associated with an increase in terminal half-life by ca. Inactive ingredients sodium chloride hydrochloric acid, concentrated sodium hydroxide water for injection. Life-threatening incidents are more likely to occur in adults over 60 years of age and those with pre-existing respiratory insufficiency or impaired cardiac function, particularly when the injection is given too rapidly or when a high dosage is administered (see section 4.4). - Saquinavir and other HIV protease inhibitors: Co-administration with protease inhibitors may cause a large increase in the concentration of midazolam. midazolam is available, the mild effect on the terminal half-life of oral midazolam tablet, increasing by 30%, indicates that the effects of roxithromycin on intravenous midazolam may be minor. Loading dose: 0.03 - 0.3mg/kg in increments of 1 - 2.5 mg. hameln pharma B.V., Leusden, The Netherlands: CONCENTRATION1 mg per mL CLOSURE13 mm UNIT OF SALE25 vials BAR CODEDYes STORAGERoom Temp. This medicinal product contains 6.84 mmol (or 157.36 mg) sodium per pre-filled syringe, equivalent to 7.9% of the WHO recommended maximum daily intake of 2 g sodium for an adult. Where the use of PVC extension sets is unavoidable, their use should be limited to 24 hours. Accord Healthcare Pty Ltd. Special caution should be exercised when administering midazolam to high-risk patients: - chronically ill or debilitated patients, e.g. Unit of measure . Upon co-administration with ritonavir-boosted lopinavir, the plasma concentrations of intravenous midazolam increased by 5.4-fold, associated with a similar increase in terminal half-life. Midazolam Injection contains 1 mg/mL or 5 mg/mL of midazolam (as the hydrochloride) as the active ingredient. If taken orally further absorption should be prevented using an appropriate method e.g. Cases of abuse have been reported. 1 ml Midazolam 5 mg/ml contains: Midazolam hydrochloride 5.56 mg equivalent to 5 mg Midazolam. Sun Pharmaceutical Industries Europe B.V. 5th Floor, Hyde Park, Hayes, 3, 11 Millington Road, Hayes, UB3 4AZ, UK. These produce a stable and well tolerated injection solution. We will be open on Wednesday 30th December 2020 for urgent deliveries over the festive period. One 50 ml pre-filled syringe made of cyclic olefin copolymer (COP) fitted with a chlorobutyl elastomer screw cap along with a bromobutyl plunger stopper, containing 50 ml of solution for injection. Midazolam elimination may be altered in patients receiving compounds that inhibit or induce CYP3A4 and the dose of midazolam may need to be adjusted accordingly (see section 4.5). There are no available studies on CYP3A4 modulation on the pharmacokinetics of midazolam after rectal and intramuscular administration. 5 mg/mL (5 mg/mL) Single Dose Glass Fliptop Vial (NDC 00409-2308-01) Available Extended Use Dates Provided by Pfizer to Assist with Emergency Syringe Shortages. midazolam, the consequence on the maximal clinical effect due to CYP3A4 inhibition will be minor while the duration of effect may be prolonged. Titration is strongly recommended to safely obtain the desired level of sedation according to the clinical need, physical status, age and concomitant medication. The risk of dependence increases with dose and duration of treatment; it is also greater in patients with a medical history of alcohol and/or drug abuse (see section 4.8). Midazolam passes in low quantities into breast milk. Each 1 ml, 2 ml, 3 ml, 5 ml, 10 ml and 18 ml ampoule contains 5 mg, 10 mg, 15 mg, 25 mg, 50 mg and 90 mg Midazolam. 15 mg/3 mL Steriluer Plastic Ampoule. Less than 1% of the dose is recovered in urine as unchanged active substance. When initiating an infusion with midazolam in haemodynamically compromised patients, the usual loading dose should be titrated in small increments and the patient monitored for haemodynamic instability, e.g., hypotension. Sedation, amnesia, impaired attention and impaired muscular function may adversely affect the ability to drive or use machines. For a full list of excipients, see section … 2-fold. Hepatic impairment reduces the clearance of i.v. dose of midazolam is administered. - Carbamazepine/phenytoin: Repeat doses of carbamazepine or phenytoin resulted in a decrease in plasma concentrations of oral midazolam by up to 90% and a shortening of the terminal half-life by 60%. midazolam hcl inj sdv 5ml: 1mg/ml: 10/bx: 1105110: hospira: 00409-2307-60: midazolam hcl inj syringe (crpjct ll) 1ml: 5mg/ml: 10/bx: 1164259: hospira: 00409-2306-12: midazolam hcl inj syringe (iscure) 2ml: 1mg/ml: 10/bx: 2580101: hospira: 00409-2305-17: midazolam hcl inj sdv 2ml: 1mg/ml: 25/bx: 2580133: hospira nova+: 00409-2305-50: midazolam … Therefore protease inhibitors should not be co-administered with orally administered midazolam. 50–150 micrograms/kg daily in divided doses (max. Additional information on indications, dosage and method of administration can be found in the SmPC. - Atorvastatin showed a 1.4-fold increase in plasma concentrations of i.v. 31787 Hameln I.V. The free base is a lipophilic substance with low solubility in water. Therefore the clinical effects may be stronger and prolonged. One oxygen scavenger pouch (proprietary iron based blend) is included in pack. dose is similar to that reported in healthy volunteers. Depending on the specific St John's Wort extract, the CYP3A4-inducing effect may vary. To bookmark a medicine you must sign up and log in. Midazolam belongs to the general class of drugs known as benzodiazepines. The elimination half-life of alpha-hydroxy-midazolam is shorter than 1 hour. Refer to the prescribing information for flumazenil, for further information on the correct use of this medicinal product. The mean half-life is greater in obese than in non-obese patients (5.9 vs 2.3 hours). Fax: +49 (0) 5151 / 80 50 124. To assess the efficacy and safety of injectable midazolam administered orally in 3 different doses in children undergoing complete dental rehabilitation under GA. The elimination half-life in cirrhotic patients may be longer and the clearance smaller as compared to those in healthy volunteers (see section 4.4). Plasma clearance is in the range of 300 - 500ml/min. 50 mg Midazolam HCI in 0.9% Sodium Chloride Injection 50 mL (1 mg/mL) Strength: 50 mg per 50 mL. Physician Prescribing Information Excipient with known effect: This medicine contains less than 1 mmol sodium (23 mg) per ml, that is to … Date of first authorisation/renewal of the authorisation. The elimination half-life is longer in patients with congestive heart failure compared with that in healthy subjects (see section 4.4). midazolam, although lesser, are reported. The physician should decide when these activities may be resumed. Midazolam is not recommended for the use in children due to the total amount of midazolam contained in the pre-filled syringes. These patients are also vulnerable to the respiratory depressant effects of midazolam and require careful monitoring of respiratory rate and oxygen saturation. There is no specific data in patients with severe renal impairment (creatinine clearance below 30 ml/min) receiving midazolam for induction of anaesthesia. Plasma concentrations of alpha-hydroxymidazolam are 12% of those of the parent compound. Respiration, pulse rate and blood pressure should ... Midazolam 100 LD50 Intravenous 50 mg/kg Mouse Midazolam 100 LD50 Intramuscular > 50 mg/kg Rat, Mouse Aspiration Hazard None anticipated from … After a single dose of i.v. Each ml contains 3.15 mg (0.14 mmol) of sodium. It has a short half-life (about an hour), therefore patients administered flumazenil will require monitoring after its effects have worn off. This medicine contains sodium. After receiving midazolam, patients should be discharged from hospital or consulting room only when recommended by treating physician and if accompanied by an attendant. After receiving midazolam parenterally, patients should be discharged from hospital or consulting room only if accompanied by an attendant. Notably, administration of high doses or long-term infusions of midazolam to patients receiving strong CYP3A4 inhibitors, e.g. Particular care should be taken when administering midazolam to a patient with myasthenia gravis. No data on exposed pregnancies are available for the first two trimesters of pregnancy. With respect to induction, it should be considered that the inducing process needs several days to reach its maximum effect and also several days to dissipate. For urgent requirements an emergency staff will be available during the festive period, except 25th December 2020 and 1st January 2021. Each ml contains midazolam (as hydrochloride) 5 mg. Each 1 ml ampoule contains midazolam (as hydrochloride) 5 mg. Each 3 ml ampoule contains midazolam (as hydrochloride) 15 mg. Each 10 ml ampoule contains midazolam (as hydrochloride) 50 mg. The required dose of midazolam may be reduced and proper monitoring of vital signs should be established (See section 4.4). during intensive care, may result in long-lasting hypnotic effects, delayed recovery and respiratory depression, thus requiring dose adjustments. Benzodiazepines increase the effects of other central nervous system depressants, including alcohol. Severe cardiorespiratory adverse events have been reported. Inselstraße 1 Midazolam is hydroxylated by the cytochrome P4503A4 isozyme and the major urinary and plasma metabolite is alpha-hydroxymidazolam. Each 2ml, 5ml and 10ml ampoule contains 2mg, 5mg and 10mg midazolam. If CNS depression is severe consider the use of flumazenil, a benzodiazepine antagonist. - St John's Wort decreased plasma concentrations of midazolam by about 20 - 40 % associated with a decrease in terminal half-life of about 15 - 17%. Midazolam Injection alcohol peak. injectable midazolam overdosage is the same as that followed for overdosage with other benzodiazepines. - patients with chronic renal failure, impaired hepatic function or with impaired cardiac function ***There have been reports of falls and fractures in benzodiazepine users. Midazolam is a potent sedative active substance that requires titration and slow administration. treatment within 1-2 hours with activated charcoal. Calculate the quantity, in mg per mL, of benzyl alco-hol in the volume of Injection taken by the formula: » Midazolam Injection is a sterile solution of Midazo-DC(r U /r S) lam Hydrochloride in Water for Injection or of Midazo-in which D is the dilution factor used in preparing the Test solution; In adults over 60 years of age, the elimination half-life may be prolonged up to four times. It is also useful for the treatment of seizures. When midazolam is given by i.v. Therefore, abrupt termination of the treatment will be accompanied by withdrawal symptoms. Midazolam injection is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to sedate a person who is having a minor surgery, dental work, or other medical procedure.
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